List of selected publications:

List of all publications

Karpinski J., Hauber I., Chemnitz J., Schäfer C., Paszkowski-Rogacz M., Chakraborty D., Beschorner N., Hofmann-Sieber H., Lange U.C., Grundhoff A., Hackmann K., Schrock E., Abi-Ghanem J., Pisabarro M.T., Surendranath V., Schambach A., Lindner C., van Lunzen J., Hauber J. Buchholz, F. (2016)
Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity.
Nature Biotechnology. On-line Feb 22. doi: 10.1038/nbt.3467. PubMed

Gebler C., Lohoff, T., Paszkowski-Rogacz M., Mircetic J., Chakraborty D., Camgoz A., Hamann M.V., Theis M., Thiede C., Buchholz F. (2016)
Inactivations of cancer mutations utilizing CRISPR/Cas9.
JNCI. doi: 10.1093/jnci/djw183. PubMed

Karimova M, Splith V, Karpinski J, Pisabarro MT, Buchholz F.
Discovery of Nigri/nox and Panto/pox site-specific recombinase systems facilitates advanced genome engineering. (2016)
Sci Rep. 2016 Jul 22;6:30130. doi: 10.1038/srep30130. PubMed

Ding, L., Paszkowski-Rogacz, M., Winzi, M., Chakraborty, D., Theis, M., Singh, S., Ciotta, G., Poser, I., Roguev, A., Chu, W.K., Choudhary, C., Mann, M., Stewart, A.F., Krogan, N., Buchholz, F. (2015)
Systems Analyses Reveal Shared and Diverse Attributes of Oct4 Regulation in Pluripotent Cells.
Cell Systems. Aug 26;2(1):141-51. doi: 10.1016/j.cels.2015.08.002. PubMed

Raychaudhuri S., Loew C., Körner R., Pinkert S., Theis M., Hayer-Hartl M.,Buchholz F., Hartl F.U. (2014)
Interplay of Acetyltransferase EP300 and the Proteasome System in Regulating Heat Shock Transcription Factor 1.
Cell. Feb 27;156(5):975-85. doi: 10.1016/j.cell.2014.01.055. PubMed

Hauber I., Hofmann-Sieber H., Chemnitz J., Dubrau D., Chusainow J., Stucka R., Hartjen P., Schambach A., Ziegler P., Hackmann K., Schröck E., Schumacher U., Lindner C., Grundhoff A., Baum C., Manz M.G., Buchholz F., Hauber J. (2013).
Highly significant antiviral activity of HIV-1 LTR-specific tre-recombinase in humanized mice.

PLoS Pathogens , 9;9(9):e1003587. PubMed

Ross, K., Sedello, A.K., Putz, G., Paszkowski-Rogacz M., Bird, A.W., Hubner, N., Mann, M., Waskow, C., Stocking, C., and Buchholz, F. (2012).
Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self renewal of hematopoietic cells.

Blood , 3;119(18):4152-61. PubMed

Chakraborty, D., Kappei, D., Theis, M., Nitzsche, A., Ding, L., Paskowski-Rogacz, M., Surendranath, V., Berger, N., Schulz, H., Saar, K., Huebner, N., and Buchholz, F. (2012).
Combined RNAi and localization for functionally dissecting long noncoding RNAs.

Nature Methods , 12:9(4):360-2. PubMed

Krastev D.B., Slabicki M., Paszkowski-Rogacz M., Hubner N.C., Junqueira M., Shevchenko A., Mann M., Neugebauer K.M., Buchholz F. (2011).
A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly.

Nat Cell Biol . Jun 5;13(7):809-18. doi: 10.1038/ncb2264. PubMed

Slabicki, M.M., Theis, M., Krastev, D.B., Samsonov, E.M., Junqueira, M., Paszkowski-Rogacz, M., Teyra, J., Heninger, A.K., Poser, I., Prieur, F., Truchetto, J., Confavreux, C., Marelli, C., Durr, A., Camdessanche, J.P., Brice, A., Shevchenko, A., Pisabarro, M.T., Stevanin, G., Buchholz, F . (2010)
A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia.

PLoS Biology , 29;8(6):e1000408. PubMed

Hutchins, J.R.A., Toyoda, Y., Hegemann, B., Poser, I., Heriche, J.K., Sykora, M.M., Augsburg, M., Hudecz, O., Buschhorn, B.A., Bulkescher, J., Comartin, D., Schleiffer, A., Sarov, M., Pozniakovsky, A., Slabicki, M.M., Schloissnig, S., Lawo, S., Pelletier, L., Stark, H., Nasmyth, K., Ellenberg, J., Durbin, R., Buchholz, F ., Mechtler, K., Hyman, A.A., Peters, J.M. (2010).
Mitotic Protein Complexes in Human Cells.

Science , 30;328(5978):593-9. PubMed

Ding, L., Paszkowski-Rogacz, M., Nitzsche, A., Slabicki, M.M., Heninger, A.K., Kittler, R., Junqueira, M., Shevchenko, A., Schulz, H., Hubner, N., Doss, M.X., Sachinidis, A., Hescheler, J., Caldarelli, A., Poser, I., Theis, M., and Buchholz, F . (2009) .A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.
Cell Stem Cell , 8;4(5):403-15. PubMed

Poser, I., Sarov, M., Hutchins, J., Heriche, J-K., Toyoda, Y., Nitzche, A., Pozniakovsky, A., Hegemann, B., Bird, A., Pelletier, L., Kittler, R., Naumann, R., Mechtler, K., Durbin, R., Stewart, A.F., Peters, J-M., Buchholz, F .,  and Hyman, A.A. (2008) .
BAC TransgeneOmics: A high-throughput method for exploration of protein function in mammals.
Nature Methods , 5(5):409-15. PubMed

Sarkar, I., Hauber, I., Hauber, J., and Buchholz, F . (2007) .
HIV-1 Proviral DNA Excision Using an Evolved Recombinase.
Science, 29;316(5833):1912-5. PubMed

Riedel , C.G., Katis, V.L., Katou ,Y., Mori, S., Itoh, T., Helmhart, W., Galova,  M., Petronczki , M., Gregan, J., Cetin, B., Mudrak, I., Ogris, E., Mechtler, K., Pelletier,  L., Buchholz , F. , Shirahige,  K., Nasmyth, K. (2006).
Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.

Nature , 441(7089):53-61. PubMed

Kittler, R., Pelletier, L., Ma, C., Poser, I., Fischer, S., Hyman, A. A., and Buchholz, F . (2005) .
RNA interference rescue by bacterial artificial chromosome transgenesis in mammalian tissue culture cells.
Proc Natl Acad Sci U S A 102 , 2396-2401. PubMed

Kittler, R., Putz, G., Pelletier, L., Poser, I., Heninger, A.K., Drechsel, D., Fischer, S., Konstantinova, I., Habermann, B., Grabner, H., Yaspo, M.L., Himmelbauer, H., Korn, B., Neugebauer, K., Pisabarro, M.T., Buchholz , F. (2004).
An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division.

Nature 432 , 1036-1040. PubMed

 

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