Wirtschaftswoche "Start-up of the week"
Newspaper "Wirtschaftswoche" votes Seamless Therapeutics as "Start-up of the week".
In this newspaper feature, start-ups pitch their business idea. This time it's Seamless Therapeutics and expert Anke Cassing casts her vote on whether she would invest.
Read the full 1-page article here.
Link to Seamless Therapeutics website
New publication from our lab
Check out our brand-new publication on "Quantification of evolved DNA-editing enzymes at scale with DEQSeq".
Congratulations to everyone involved!
Frank Buchholz honoured for his commitment to transfer innovation from research to industry
On 6 September 2023, UNIPRENEURS honoured 20 outstanding professors & founders for their achievements in transfer of innovation who had been selected from 700 nominations.
Prof. Dr. Frank Buchholz, head of the Medical Systems Biology research group at the Faculty of Medicine Carl Gustav Carus, is one of three prize winners from TU Dresden, along with Prof. Dr. Gerhard Fettweis and Prof. Dr. Karl Leo.
The award recognises Frank Buchholz’s enormous research success and outstanding contribution to the development of genome editing technology, especially with regard to possible therapeutic applications.
His research has already been awarded the GO-Bio Prize of the BMBF, among others. Last year, Frank Buchholz and his team around Anne-Kristin Heninger und Felix Lansing founded the Dresden-based start-up Seamless Therapeutics GmbH, whose technology platform reprogrammes recombinases for the purpose of repairing disease-causing genetic alterations.
Complete press release of TU Dresden
UNIPRENEURS LinkedIn (video clip)
Frank Buchholz and Seamless Therapeutics GmbH on designer recombinases competing with CRISPR
In our latest news release, Frank Buchholz (TU Dresden) and Anne-Kristin Heninger (Seamless Therapeutics GmbH) look at how designer recombinases have become a strong competitor of CRISPR. Explaining their research, Frank and Anne also show the enormous potential of designer recombinases.
Please find the complete MIT Technology Review article here (PDF, German)
Laborjournal on Seamless Therapeutics
In their news article in Laborjournal, the Dresden-based start-up Seamless Therapeutics reflects on programmable recombinases that operate independently of the cell's own DNA repair system and could thus in future make it possible to cure the disease haemophilia A, for which currently merely the symptoms are treated.
Frank Buchholz is a founding member of the start-up and head of the Medical Systems Biology research group at the Faculty of Medicine Carl Gustav Carus of TU Dresden, which developed the recombinase technology.
To the article in “Laborjournal”
Jenna Hoersten represented the Buchholz Lab at the 26th ASGCT Annual Meeting in Los Angeles
The American Society of Gene and Cell Therapy’s (ASGCT) Annual Meeting is considered the premier event for professionals in gene and cell therapy.
Our PhD student Jenna participated at this year's ASGCT Annual Meeting in Los Angeles.
The abstract titled “Enhancing the precision of designer site-specific recombinases: Methods for surveying sequence specificity and mitigating potential off-target effects” was presented during the first poster session on May 17th.
All abstracts are published in Molecular Therapy (DOI).
New publication on tyrosine-type site-specific recombinases
Our new paper “Discovery and characterization of novel Cre-type tyrosine site-specific recombinases for advanced genome engineering” in collaboration with DKMS Life Science Lab has just been published at Nucleic Acids Research. Check it out:
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad366/7157522?login=false
Congratulations to everyone involved: Milica Jelicic, Lukas Theo Schmitt, Maciej Paszkowski-Rogacz, Angelika Walder, Nadja Schubert, Jenna Hoersten, Duran Sürün, and Frank Buchholz!
Frank Buchholz participating in open discussion on genetic research
Is there a gene for a bigger and more efficient brain? Can genome surgery soon free us from all diseases? Do my genes determine my character?
During audience discussions, experts exchange views on these and other questions in a relaxed atmosphere. Frank Buchholz will be one of the experts.
On 26 April 2023 | 6-8:30 PM
At Deutsches Hygienemuseum Dresden (free admission)
The DRESDEN-concept event series "Reden wir über..." introduces researchers to a public audience and fosters exchange about science and life.
Please click here to learn more about the event.