Molecular Scissors

2016

Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity2013

Molecular surgery of HIV with Tre recombinase: For the first time the effectiveness of molecular scissors (Tre recombinases) to specifically remove HIV is demonstrated in an organism.

In collaboration with the Hamburger Heinrich-Pette Insitute (HPI) we could demonstrate a highly significant antiviral effect of the Tre recombinase in a humanized mouse model. Previous experiments have already shown that the Tre recombinase has been effective to remove the HIV genetic material from HIV-infected host cells and thus reverse the infection. The current studies prove that the Tre recombinase can also remove HIV from infected human cells transplanted into mice without measurable side effects. These findings are an important step towards future clinical trials aiming at a cure of HIV.

We have been working over 15 years in the field of site-specific recombinases to develop innovative HIV therapies. Worldwide, there are about 34 million people infected with HIV.

Link to publication Hauber et al. 2013

Update-button…now over 199,000 views; more then any other manuscript ever published in PLoS Pathogens!

 

Other links to articles on Tre recombinase:

Location / Link Article Language
Der Tagesspiegel Science Match 2017 in Dresden german
FAZ Der Hoffnungsträger german
3Sat – nano Enzym-Attacke auf HI-Viren german
Bild.de Forscher entwickeln Mittel gegen AIDS german
ARD Mittagsmagazin Durchbruch in der AIDS-Forschung german
Sächsische Zeitung Forschungsergebnisse wecken Hoffnung auf Heilung von AIDS german
SZ Online TU-Forscher kämpfen gegen HI-Virus german
Dresdner Neuste Nachrichten Dresdner Forscher wecken Hoffnung auf Heilung von AIDS german
Dresdner Neuste Nachrichten Dresdner Forscher bekämpfen AIDS-Erreger mit molekularer Schere german
Mitteldeutsche Zeitung Neue Ergebnisse wecken Hoffnung auf Heilung german
Laborwelt HIV-Schere wirkt bei Mäusen german
ÄrzteZeitung Neue Hoffnung auf Heilung von HIV/Aids german
Reddit Science Laboratory mice completely cured of HIV through Tre-Recombinase. Clinical trials planned for 2015. english
Die Welt Forscher befreien Labormäuse von Aids-Viren german
n-tv Lichtblick für HIV-infizierte Menschen – Labormäuse von Aids-Viren befreit german
Pharmazeutische Zeitung Molekulare Schere schneidet Virus aus german
Die Welt am Sonntag Auch die DNA wächst zusammen german
New York Daily News HIV removed from mouse cells with enzyme: report english

 

Comments are closed.