2016
2013
Molecular surgery of HIV with Tre recombinase: For the first time the effectiveness of molecular scissors (Tre recombinases) to specifically remove HIV is demonstrated in an organism.
In collaboration with the Hamburger Heinrich-Pette Insitute (HPI) we could demonstrate a highly significant antiviral effect of the Tre recombinase in a humanized mouse model. Previous experiments have already shown that the Tre recombinase has been effective to remove the HIV genetic material from HIV-infected host cells and thus reverse the infection. The current studies prove that the Tre recombinase can also remove HIV from infected human cells transplanted into mice without measurable side effects. These findings are an important step towards future clinical trials aiming at a cure of HIV.
We have been working over 15 years in the field of site-specific recombinases to develop innovative HIV therapies. Worldwide, there are about 34 million people infected with HIV.
Link: Hauber et al. 2013
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Other links to articles on Tre recombinase.:
| Location / Link | Article | Language |
| Der Tagesspiegel | Science Match 2017 in Dresden | german |
| FAZ | Der Hoffnungsträger | german |
| 3Sat – nano | Enzym-Attacke auf HI-Viren | german |
| Bild.de | Forscher entwickeln Mittel gegen AIDS | german |
| ARD Mittagsmagazin | Durchbruch in der AIDS-Forschung | german |
| Sächsische Zeitung | Forschungsergebnisse wecken Hoffnung auf Heilung von AIDS | german |
| SZ Online | TU-Forscher kämpfen gegen HI-Virus | german |
| Dresdner Neuste Nachrichten | Dresdner Forscher wecken Hoffnung auf Heilung von AIDS | german |
| Dresdner Neuste Nachrichten | Dresdner Forscher bekämpfen AIDS-Erreger mit molekularer Schere | german |
| Mitteldeutsche Zeitung | Neue Ergebnisse wecken Hoffnung auf Heilung | german |
| Laborwelt | HIV-Schere wirkt bei Mäusen | german |
| ÄrzteZeitung | Neue Hoffnung auf Heilung von HIV/Aids | german |
| Reddit Science | Laboratory mice completely cured of HIV through Tre-Recombinase. Clinical trials planned for 2015. | english |
| Die Welt | Forscher befreien Labormäuse von Aids-Viren | german |
| n-tv | Lichtblick für HIV-infizierte Menschen – Labormäuse von Aids-Viren befreit | german |
| Pharmazeutische Zeitung | Molekulare Schere schneidet Virus aus | german |
| Die Welt am Sonntag | Auch die DNA wächst zusammen | german |
| New York Daily News | HIV removed from mouse cells with enzyme: report | english |